I WILL ALWAYS LOVE YOU

I Will Always Love You

If I
Should stay
I would only be in your way
So I'll go
But I know
I'll think of you every step of the way

And I ...
Will always
Love you, oohh
Will always
Love you
You
My darling you
Mmm-mm

Bittersweet
Memories
That is all i'm taking with me
So good-bye
Please don't cry
We both know I'm not what you
You need

And I..
Will always love you
I..
Will always love you
You, ooh

I hope
life treats you kind
And I hope you have all you've dreamed of
And I wish you joy
and happiness
But above all this
I wish you love

And I ...
Will always love you
I..
Will always love you

I, I will always love
You..
You
Darling I love you
I'll always
I'll always
Love
You..
oooh
ooohhh

Endless Love

Endless Love

My Love
There's only you in my life
The only thing that's right

My first love
Yu're every breath that I take
You're every step I make

And I
I wnat to share
All my love with you
And your eyes
They tell me how mych you care
Oh yes
You will always be
My endless love

Two hearts
Two hearts that beat as one
Our lives hve just begun
And foreever
I;ll hold you close in my arms
I can't resist your charms

And love
I;d play the fool
For you
I'm sure
You know I don't mind
'Cause baby
You mean the world to me
I know I've found in you
My endless love

And love
I'd play the fool
For you
I;m sure
That you know I don't mind
'Cause baby
You'll be the only one
'Cause no one can deny
This love I have inside
And I'll give it all to you
My love My ove, my love
My endless love

Billie Jean lyrics

Bille Jean

She was more like a beauty queen from a movie scene
I saind, "Don't mind but what do you mean I am the one
Who will dance on the floor in the round?"
She saind, " I am the one who will dance on the floor in the round"

She told me her name was Bille Jean
As she caused a scene
Then evey head turned with eyes that dreamd of being the one
Who will dance on the floor in the round

People always told me, " Be careful of what you do
And don't go around breaking young girls hearts"
And mother always told me, "Be carefule of who you love
And be careful of what you do nbecause the lie becomes the truth"

Beiie Jean is not my lover
She's just girl who claims that I am the one
But the kid is not my son
She says I am the one but the kid is not my son

For forty days and for forty nights ,The law was on her side

But who can stand when she's in demand ,Her schemes and plans
'Cause we danced on the floor in the round

So take my strong advice
Just remember to always think twice
Do think twice, do thnk twice
 
She told my baby, we were dancing still three
Then she looked at me, then showed a photo
My baby cried because his eyes were like mine, oh no
 Though we'd dance on the floor in round, baby

People always told me, " Be careful of what you do

And don't go around breaking young girls hearts"
But she came and stood right by me then the smell of sweet perfume
This happend much too soon, she called me to her room

Billie Jean is not my lover
She's just a girl who claims that I amd the one
But the kid is not my son

Billie Jean is not my lover

She's just a girl who claims that I amd the one
But the kid is not my son

She says I am the one
But the kid is not my son

She says I am the one

But the kid is not my son

Billie Jean is not my lover

She's just a girl who claims that I amd the one

But the kid is not my son


She says I am the one

But the kid is not my son

She says I am the one

She says he is my sun
She says I am the one

Billie Jean is not my lover Billie Jean is not my lover
Billie Jean is not my lover



---
















 

Why Use a Clinical Data Warehouse?

source: http://www.pharmexec.com/pharmexec/article/articleDetail.jsp?id=630131

Why Use a Clinical Data Warehouse?

Oct 6, 2009

By: Niels Buch Leander, Philip Puls

Because of an increasing pressure to get products to market, there are four challenges that mean more data must be handled within a shorter time span:

1. There is an almost explosive growth in data resulting from clinical trials: more trials are conducted, each trial collects more data and trial designs have become more complex.

2. Companies as well regulatory agencies are moving towards highly standardized study reporting and data exchange such as SDTM (Study Data Tabulation Model) — and this becomes more challenging as data volumes grow.

3. Adaptive business models are indispensable when traditional pharmaceutical companies outsource much of the clinical operation and statistical analysis, and data need to be exchanged quickly in a structured and uniform manner.

4. Many companies take over new products or late stage development projects, which then have to be transferred quickly into the company's systems in order to secure the continuation of the clinical development plan.

These challenges greatly intensify the pressure on the departments dealing with data management and statistics, departments that are already struggling to keep up with the workload and that often become bottlenecks in the release of the study data for any further usage. Consequently, valuable information may be unavailable and the pharmaceutical company loses time, money and opportunities — and may even face regulatory interference.

A clear solution to these challenges is a clinical data warehouse (CDW).

The value proposition of standardization

CDW's central benefit is that everyone can access the same data in near-real time. This benefit cannot be underestimated. For instance, when biostatisticians, statistical programmers, bio-modelers and pharmacokineticians have access to a statistical computing environment, including a standard program library, they can focus on data analysis, as they are supposed to, not on programming. And when people involved in medical writing, pharmacovigilance and data management have access to a patient browser, they can focus on information analysis, as they are supposed to, and not on discussions about data interpretations arising from discrepancies and lack of standards. Moreover, when medical writers, trial managers, health economists and epidemiologists can perform ad hoc analysis across trials, they can focus on future trial design, cost savings and adaptation of running trials, as they are supposed to, instead of blindly repeating past mistakes.

  

By being first and foremost a drive towards standardization, a CDW presents the pharmaceutical company with the following benefits:

• better use of internal resources
• reduction in critical time path for statistical analysis
• standard exchange of data with CROs, partners and regulatory agencies
• cross-trial analysis and leveraged use of historical data
• globalization and knowledge sharing
• compliance with regulations.

A CDW is therefore the natural solution to a rapidly growing need of organizing, storing and sharing clinical data from different systems. The availability of clinical data across a company saves time, reduces costs and facilitates compliance.

How to implement a CDW

However, the implementation of a CDW is an immense undertaking. It will undoubtedly involve a number of key resources in the company, which may put further pressure on an already strained organization. If the CDW is to be delivered successfully and on time, it is therefore crucial to rely on a number of pre-designed solutions as well as an implementation partner with a clear design methodology and a proven track record of implementation projects.

In the early stages of the CDW design, it is important to focus on the business process and not on IT. Yet, since a CDW is essentially a drive towards standardization, it is vital that the standardization process be commenced as early as possible.

The key to a successful implementation of a CDW is to use a common IT Project Management Model with a focus on IT governance as well as a strong, dedicated steering group. The project management group must consist of a senior business project manager and project manager who is responsible for the IT solution. The project team should be heavily represented by biostatisticians and statistical programmers, as well as subject matter experts from the software vendor and implementation partner. Finally, it is important to have adequate representation from the quality department.

It is advantageous to break up the project into smaller releases that individually provide benefits to the company. This approach secures user participation and allows users to provide feedback that can be used to adjust the design of future releases.

The objective of the CDW is typically to become the source of the statistical analysis and the foundation upon which to automate the analysis and reporting that are part of a submission. As a result, the CDW has a potential impact on the final product and should be rated critical in terms of GCP. Consequently, the system has to be implemented in compliance with GAMP and ICH and 21 CFR Part 11.

As there are few off-the-shelf systems available that offer the full solution, it is to be expected that some company specific adaptation is needed, especially in relation to data load and metadata management solutions. This, however, increases both the validation effort and the complexity, thereby raising the project risk profile. In order to mitigate risks and reduce validation efforts, it is crucial to select an implementation partner with a set of accelerators upon which the system can be based. The accelerators should facilitate reduction in system specification, design, construction and test of the CDW modules.

The benefits of a CDW are obvious. Yet, since the implementation is both complex and demanding, the CDW only lives up to its full business potential if based on a solid design that both supports the drive towards standardization and eases the implementation.

펌: 윈도우8 자동로그인 암호 넣지 않는 방법

윈도우8 자동로그인 암호 넣지 않는 방법
source: http://cdmanii.com/2525

윈도우8 자동로그인 하는 방법을 통해서 암호를 넣지 않고 바로 윈도우 화면을 보는 방법을 설명해보겠습니다. VMware 를 통해서 윈도우8 개발자 버전을 설치 하고 노트북에도 설치해서 이것저것 써보는데 재부팅 할때마다 암호 입력 번거로우실겁니다. 이때 간단한 암호 입력으로 자동으로 로그인이 되도록 할 수 있습니다. 물론 보안을 위해서는 화면보호기 등에는 암호를 걸어놓아야겠죠. 암호를 아예 없는 암호로 둘 수 도 있지만 그건 권장 되지 않습니다. 아래 방법을 통해서 입력한 암호로 윈도우8 자동로그인 하는 방법을 배워보겠습니다.

윈도우8 화면에서 "윈도우키 + R" 를 누릅니다. netplwiz 를 입력 후 OK 를 누릅니다.

Users must enter a user name and password to use this computer 체크를 해제 합니다. OK 버튼을 누릅니다.

자신의 계정의 암호를 2번 정확하게 입력 합니다. OK 버튼을 누릅니다.

이제부터는 재부팅을 했을 때 윈도우8 암호를 다시 입력하지 않아도 자동으로 로그인이 되버리는것을 볼 수 있습니다. 참고로 매트로 UI 화면에서 윈도우 데스크탑 화면으로 가는 방법은 ESC 키를 누르는 것 입니다.